Pathophysiology of diabetes nephropathy and atherosclerosis

The smooth muscles of the blood vessels are also hyperactive in diabetes. We examine the epidemiological evidence that suggests that hyperglycemia and glycemic control are CVD risk factors. Studies on filtration fraction, an indirect measure of glomerular capillary pressure, have shown that, in patients with diabetes, glomerular capillary pressure is elevated and may synergise with the metabolic perturbation in the pathophysiology of the disease.

Acute stimulatory effects of glucose infusion on leukocyte rolling and adherence to the endothelium have been demonstrated in the rat. Moreover, in vitro studies tend to be overextrapolated and can be misleading.

Spontaneous hypoglycemia in adults is of two principal types: Improved mouse models and more clinical trials, for example investigating the combined effect of improved glycemic control and lipid lowering in both type 1 and type 2 diabetes, are urgently needed in order to find ways to treat or prevent cardiovascular complications of diabetes.

Risk Factors Hypertension and hyperglycaemia are seen as the major contributing factors to the development of nephropathy.

And remember this figure will be from the U. Therefore, other approaches are necessary to understand the potential role of hyperglycemia in the pathogenesis of cardiovascular disease.

How Can Diabetes Cause Atherosclerosis?

Intensive intervention in T2D patients can reduce the progression of nephropathy and possibly slows progression of renal impairment Schrier et al. Glycerol is converted to glucose for cellular use. Central to diabetes related risk factors for atherosclerosis is hyperglycaemia from insulin deficiency and insulin resistance.

These findings are similar to those observed in the Pathophysiology of diabetes nephropathy and atherosclerosis follow-up of the DCCT cohort. The resulting increase in glomerular pressure and the consequent disproportionate transmission of the systemic pressure to the glomerular circulation synergise with the raised glucose levels in mediating glomerular damage.

Diabetic nephropathy

It is not clearly understood why a PWD progresses to renal failure and others do not, as there does not appear to be a casual correlation between good or poor control.

There usually be new tools and supplies and medications coming out for along with diabetes. Podocyte detachment has been positively correlated with urinary albumin excretion and increasing podocyte detachment is associated with decreased permselectivity of the glomerulus and progressive albuminuria.

Although variations in fall in GFR exist between patients, in the last few decades with the introduction of inhibitors of the renin angiotensin aldosterone system RAASand more intense glycaemic and hypertension treatment, the time from the onset of clinical albuminuria to death has increased from 7 to 21 years.

Unlike type 1 diabetic patients, individuals with type 2 diabetes are generally resistant to DKA because their pancreatic insulin production is often sufficient to prevent ketone formation. Thus, lipids are likely to play a more important role than glucose in patients with established type 2 diabetes.

Increased tissue resistance to insulin generally occurs first and is eventually followed by impaired insulin secretion. In vivo responses are a complex result of interactions between many different risk factors, and it is often difficult to know to what extent hyperglycemia might have contributed to a specific outcome.

Furthermore, diabetic nephropathy is associated with an increased risk of cardiovascular morbidity and mortality. Arent we likely to start starting to be more concern about diabetes?

In the glomerulus hyperglycemia is paralleled by local upregulation of angiotensin-2 that, by reducing afferent and, to a lower degree, efferent arteriolar tone, alters glomerular capillary auto-regulation.

It is likely that the pathophysiology of diabetic nephropathy involves a multifactorial interaction between metabolic and hemodynamic factors.

Diabetes and atherosclerosis: is there a role for hyperglycemia?

The severity of hyperglycaemia and presence of hypertension were in evidence in the U. Firstly, analysis on the microvascular complication of diabetes nephropathy will be discussed and secondly, the macrovascualr complication of atherosclerosis.

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In this early phase, the prominent clinical manifestation of diabetic renal disease is characterised by an elevation of renal plasma flow and by an increase in glomerular filtration rate GFR.

However, epidemiological studies only indicate associations, and provide no evidence of causality. Since major reviews on this topic by our group over a decade ago 1,2there have been major advances in this area. It is widely accepted that the rise in albuminuria reflects an increased transglomerular flux of albumin as a consequence of an increased transglomerular pressure gradient and damage of the glomerular filtration barrier.

Diabetic Nephropathy Pathophysiology

However, there was no suggestion of any benefit of glycemic control that would have been predicted from the epidemiological evidence. Severe physiologic stress may induce DKA in those with type 2 diabetes.

Pathophysiology of Diabetes Nephropathy and Atherosclerosis

Release of increased free radicals promotes increased platelet aggregation with elevated levels of plasminogen activator inhibitor type 1 and impaired fibrinolysis, allowing an increased inflammatory response to occur Morgensenpp.Diabetes Pathophysiology July - Brian L. Mealey, DDS, MS Introduction.

An understanding of the pathophysiology of diabetes rests upon knowledge of the basics of. Dec 03,  · Diabetes occurs when there is a dis-balance between the demand and production of the hormone insulin.

Control of blood sugar. When food is taken, it is broken down into smaller components.3/5(12). Diabetes is a major risk factor in the development of diabetes nephropathy and atherosclerosis. The person with diabetes (PWD) is at increased risk of mortality and morbidity than the general population but these are further increased in the presence of complications.

May 03,  · Generally, diabetic nephropathy is considered after a routine urinalysis and screening for microalbuminuria in the setting of diabetes. Patients may have physical findings associated with long-standing diabetes mellitus. Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function occurring in those with diabetes mellitus.

Protein loss in the urine due to damage to the glomeruli may become massive, and cause a low serum albumin with resulting generalized body swelling (edema) and result in the nephrotic syndrome.

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Pathophysiology of Diabetes Nephropathy and Atherosclerosis

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Pathophysiology of diabetes nephropathy and atherosclerosis
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